What are muscles responsible for?
40% of our body mass!
breathing
eating
posture
walking
reflexes
heat generation
metabolism
Muscle loss is called - atrophy or wasting
Muscle loss causes:
disuse
injury
starvation
diseases such as cancer
sepsis
neuromuscular disorders
ageing
Muscle mass is reduced about 1/3 when humans reach the age of 50-80
The University of Western Australia
has researched many things about muscles.. not only how they affect they body and also the heart as well
They took aged mice and this was exactly what they did!!
SOURCE: (http://www.anhb.uwa.edu.au/research/student-projects/muscle-regeneration)
Weights – Body weights, muscle weights
- Levels of muscle IGF-1 in young and old transgenic mice (IGF-1 elisa)
- Muscle fibre type changes (Immunostaining)
- Myofibre number and size (cross-sectional area) changes (HandE staining)
- Neuromuscular Junctions – morphology and innervation (Immunostaining and Imaging on Confocal lazer microscope)
- Motoneuron counts in the spinal cord (toluidine blue staining/developing other methods)
- Oxidative stress measurements
- Levels of neurotrophic factors (qPCR/mRNA levels/Western Blots)9. Signalling pathways – Phosphoprotein signalling (Western Blots)
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